Related Experiment Video
Updated: Jun 28, 2026
Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model
Published on: August 11, 2018
Reducing post-surgical adhesions utilizing a drug-enhanced device: sodium carboxymethylcellulose aqueous
Helen Cui1, Michel Gensini, Ram Kataria
1Center for Biomaterials and Advanced Technologies, Medical Devices Group, A Division of Ethicon, A Johnson & Johnson Company, Rt 22W, Somerville, NJ 08876, USA.
Abstract:
Post-surgical adhesion formation has numerous deleterious side effects in a wide variety of surgical settings. Physical barriers used together with laparoscopy were developed to reduce tissue trauma seen with open procedures. However, despite surgeons' meticulous techniques and the use of such barriers, adhesion formation remains a serious clinical problem, creating complications that cost the health care system over $1 billion annually. Our laboratories have combined a previously marketed drug, Tranilast, with a sodium carboxymethylcellulose (NaCMC) gel in a sustained release formulation using poly(p-dioxanone) (PDO) to provide a locally delivered medicated device that significantly reduces adhesions. This paper describes the preparation of the gel and the sustained release formulation, its key physical properties, and its sustained release kinetics. Pre-clinical data on inhibition of adhesion formation by the sustained release poly(p-dioxanone)/sodium carboxymethylcellulose/Tranilast drug enhanced device are also presented.
