[Bio-database literacy and its application with cis-regulatory modules to find novel drug target proteins]

We have expected Bioinformatics as tools to extract new knowledge from whole genome sequences of various organisms. In the post-genome era, to find some knowledge of the gene regulation including locations of cis-regulatory elements, modules and those combinations became one of the big challenges on Bioinformatics field. Because, it is difficult and inefficient to determine all possible combinations of cis-regulatory elements by bio-chemical approach. However, computational ways might allow us to find out all cis-elements within a time frame. In this review, we introduce the current status of public available databases on Internet comparing our original database for the cis-modules. We also explain our new mathematical measurement to characterize sequence patterns for cis-elements of each transcription factors and its application to predict the gene expression regulation network.