Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety, tolerability, and efficacy of flexible-dose tavapadon for Parkinson's disease (TEMPO-2): a phase 3, randomised, placebo-controlled, double-blind trial.

The Lancet. Neurology·2026
Same author

MRI-Only Simulation for Prostate MRI-Guided SBRT.

Practical radiation oncology·2026
Same author

Status and challenges of MRI-only simulation for stereotactic body radiation therapy.

Journal of radiosurgery and SBRT·2026
Same author

Tavapadon as Adjunctive Treatment for Parkinson Disease: The TEMPO-3 Randomized Clinical Trial.

JAMA neurology·2026
Same author

Closing the Gate Before the Horse is out of the Barn: A Model to Effectively Predict the First Fall in Patients with Parkinson's Disease.

Movement disorders clinical practice·2026
Same author

Phosphorylated alpha-synuclein skin biopsy alters diagnosis in two out of three patients: Initial findings in a tertiary center.

Parkinsonism & related disorders·2026

Related Experiment Video

Updated: Jun 28, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Reoperation for suboptimal outcomes after deep brain stimulation surgery.

Tina-Marie Ellis1, Kelly D Foote, Hubert H Fernandez

  • 1Department of Neurology, Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA.

Neurosurgery
|November 5, 2008
PubMed
Summary

Reoperations for deep brain stimulation (DBS) lead placement can significantly improve outcomes in patients with Parkinson's disease, essential tremor, and dystonia. Timely identification and revision of suboptimal leads are crucial for enhancing patient results.

More Related Videos

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation
06:32

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation

Published on: July 14, 2023

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Related Experiment Videos

Last Updated: Jun 28, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation
06:32

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation

Published on: July 14, 2023

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Area of Science:

  • Neurosurgery
  • Neurology
  • Biomedical Engineering

Background:

  • Suboptimal deep brain stimulation (DBS) lead placement is a potential cause of unsatisfactory outcomes in patients with Parkinson's disease (PD), essential tremor (ET), and dystonia.
  • Previous studies indicate that a significant portion of patients experiencing suboptimal results have misplaced leads, necessitating revision surgery.

Purpose of the Study:

  • To evaluate the clinical outcomes of patients undergoing reoperation for deep brain stimulation (DBS) lead repositioning or replacement due to suboptimal placement.
  • To determine the impact of revision surgery on motor function and quality of life in patients with movement disorders.

Main Methods:

  • A retrospective chart review was conducted on patients who underwent DBS lead reoperation for suboptimal clinical benefit.
  • Data collected included patient demographics, diagnosis, pre- and post-reoperation motor scores (UPDRS III, TRS, UDS), quality of life measures (PDQ-39), and Clinician Global Impression scores.
  • Exclusion criteria included lead replacement due to infection or hardware malfunction.

Main Results:

  • Reoperation in 11 PD, 7 ET, and 4 dystonia patients showed significant improvements: 24.4% on UPDRS III for PD, 60.4% on TRS for ET, and 12.8% on UDS for dystonia.
  • Quality of life measures for PD patients also improved across mobility, daily activities, emotion, stigma, and discomfort.
  • Clinician Global Impression scores indicated "very much improved" or "much improved" outcomes in a majority of patients across all diagnoses.

Conclusions:

  • Suboptimal deep brain stimulation (DBS) lead placement can lead to unsatisfactory outcomes in movement disorder patients.
  • Reoperation and repositioning/replacement of DBS leads in carefully selected patients can significantly improve motor function and quality of life.
  • Timely identification of lead placement issues is essential for optimizing therapeutic benefits of DBS.