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Updated: Jun 28, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Obesity and aging have divergent genomic fingerprints
1Laval Hospital Research Center and Faculty of Pharmacy, Laval University, Québec, QC, Canada.
Abstract:
Aging is associated with increased visceral fat, and recent studies suggested that in turn, visceral fat could influence longevity. We therefore tested whether obesity could be a condition of premature aging. Whole-genome microarray analysis of gene expression between obese mice, aged mice and their respective controls, revealed that long-term adaptations in gene expression in visceral fat upon aging are different from those occurring during fat accretion in young adult animals, suggesting specific, divergent and non overlapping pathways of regulation.
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