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[Efficacy and tolerance of disopyramide in arrhythmia associated with sinus node dysfunction]
1Service de cardiologie A, CHU de Brabois, Vandoeuvrelès-Nancy.
Archives Des Maladies Du Coeur Et Des Vaisseaux
|June 1, 1991
Summary
Delayed-release Disopyramide effectively managed tachyarrhythmias in most patients with sinus node dysfunction. However, electrophysiological studies indicated a potential negative impact on sinus node function, despite good clinical tolerance.
Area of Science:
- Cardiology
- Clinical Electrophysiology
Context:
- Sinus node dysfunction (SND) and supraventricular/ventricular excitability present complex challenges in arrhythmia management.
- Disopyramide is an antiarrhythmic medication with potential effects on cardiac conduction.
Purpose:
- To evaluate the impact of delayed-release Disopyramide (500 mg daily) on sinus node function in patients with SND and tachyarrhythmias.
- To assess the clinical efficacy and electrophysiological effects of Disopyramide in this patient population.
Summary:
- 12 subjects with SND received 5 days of delayed-release Disopyramide.
- ECG, Holter monitoring, and electrophysiological studies were conducted pre- and post-treatment.
- Disopyramide suppressed clinical tachyarrhythmias in 8 of 11 subjects; one patient discontinued due to urinary retention.
Impact:
- Electrophysiological studies suggested a trend towards impaired sinus node function (increased sinoatrial conduction and corrected sinus node recovery times), though not statistically significant.
- Holter monitoring indicated good clinical tolerance with no significant changes in maximal sinus pause.
- A discordance exists between electrophysiological findings and clinical tolerance regarding Disopyramide's effect on sinus node function in bradycardia-tachycardia syndrome.