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Related Experiment Videos

Multiple sclerosis associated with vitamin B12 deficiency.

E H Reynolds1, J C Linnell, J E Faludy

  • 1Department of Neurology, King's College Hospital, London, England.

Archives of Neurology
|August 1, 1991
PubMed
Summary

This study reports an unusual association between multiple sclerosis (MS) and vitamin B12 deficiency in 10 patients. The findings suggest a potential link requiring further investigation into vitamin B12 metabolism in MS.

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Area of Science:

  • Neurology
  • Hematology
  • Nutritional Science

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Vitamin B12 deficiency typically presents with anemia and neurological symptoms, usually in older individuals.
  • The co-occurrence of MS and vitamin B12 deficiency, especially in younger patients, is rarely reported.

Purpose of the Study:

  • To describe a novel association between multiple sclerosis and vitamin B12 deficiency.
  • To investigate the clinical features and hematologic profiles of patients with this co-occurrence.
  • To explore potential mechanisms underlying the observed relationship.

Main Methods:

  • Case series describing 10 patients with coexisting multiple sclerosis and vitamin B12 deficiency.

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  • Clinical data collection including age of onset, symptoms, and neurological findings.
  • Hematologic and biochemical analyses, including erythrocyte cobalamin levels and assessment for pernicious anemia.

    • Main Results:

    • Ten patients presented with clinical features typical of MS, with eight diagnosed before age 40.
    • Nine patients exhibited hematologic abnormalities, though only two were anemic.
    • Low erythrocyte cobalamin levels were found in all six patients tested; only two had pernicious anemia, suggesting unexplained vitamin B12 deficiency in others.

    Conclusions:

    • An unusual association between multiple sclerosis and vitamin B12 deficiency is presented.
    • The findings suggest a potential link beyond coincidence, possibly involving vitamin B12 binding or transport.
    • Further research into vitamin B12 metabolism in MS is warranted to understand this neurological disorder better.