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Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
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Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

HIV infection in the elderly.

Nancy Nguyen1, Mark Holodniy

  • 1University of the Pacific School of Pharmacy and Health Sciences, Stockton, CA, USA.

Clinical Interventions in Aging
|November 6, 2008
PubMed
Summary

The number of older adults living with HIV is increasing globally. Effective management of HIV in patients over 50 requires awareness of evolving epidemiology and treatment strategies.

Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Public Health

Background:

  • An increasing number of individuals over 50 years old are living with HIV.
  • HIV infection is transitioning to a chronic condition manageable with highly active antiretroviral therapy (HAART).
  • Globally, an estimated 2.8 million people aged 50 and above are living with HIV/AIDS.

Purpose of the Study:

  • To review the epidemiology of HIV in older adults.
  • To discuss current HIV treatment strategies.
  • To highlight medical management considerations for HIV-infected geriatric patients.

Main Methods:

  • Review of epidemiologic data on HIV prevalence in older adults.
  • Discussion of highly active antiretroviral therapy (HAART) impact on survival.

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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

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  • Analysis of medical management challenges in the context of aging and HIV.
  • Main Results:

    • HIV survival rates have significantly improved due to HAART.
    • There is a growing population of older adults diagnosed with and living with HIV.
    • Clinicians must adapt to managing HIV as a chronic condition in aging patients.

    Conclusions:

    • HIV management in older adults requires specialized knowledge of geriatric considerations.
    • Awareness of HIV trends in the aging population is crucial for healthcare providers.
    • This review aims to equip clinicians with information for managing HIV in elderly patients.