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Subclavian Vein Blood Sampling in Conscious Rats
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Heparinised saline or normal saline?

Anand Kannan1

  • 1Main Theatres, Box 206, Addenbrookes' NHS Foundation Trust, Cambridge, CB2 OQQ.

Journal of Perioperative Practice
|November 6, 2008
PubMed
Summary

Heparinized saline flushes for arterial and central venous lines lack evidence. Normal saline is a suitable alternative, potentially avoiding adverse effects associated with heparinized saline.

Area of Science:

  • Medical practice
  • Clinical research
  • Vascular access

Background:

  • Heparinized saline is commonly used to maintain patency of arterial and central venous lines.
  • Clinical practice guidelines often recommend heparinized saline for catheter maintenance.

Purpose of the Study:

  • To evaluate the evidence supporting the use of heparinized saline over normal saline for maintaining arterial and central venous line patency.
  • To identify potential adverse effects associated with heparinized saline use.

Main Methods:

  • A comprehensive literature search was conducted using Ovid CINAHL and Medline databases.
  • Hand-searching of bibliographies from clinical and research articles was performed.
  • Keywords included 'heparin', 'normal saline', 'arterial', 'haemodynamic lines', and 'catheters'.

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Main Results:

  • No evidence was found to support the use of heparinized saline over normal saline for maintaining line patency.
  • The use of heparinized saline may be associated with adverse effects.

Conclusions:

  • Current evidence does not support the routine use of heparinized saline for arterial and central venous lines.
  • Normal saline is a viable alternative, potentially reducing risks.
  • Further research may be needed to clarify optimal flushing protocols.