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Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Related Experiment Video

Updated: Jun 28, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Quorum sensing and Candida albicans.

Michael Kruppa1

  • 1Department of Microbiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-1708, USA. kruppa@etsu.edu

Mycoses
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

Candida albicans regulates its morphology based on cell density, mimicking bacterial quorum sensing (QS). This discovery offers new insights into fungal virulence and cross-kingdom interactions.

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Area of Science:

  • Microbiology
  • Mycology
  • Infectious Diseases

Background:

  • Candida albicans is a common nosocomial pathogen.
  • It possesses virulence factors like enzymes and morphogenic switching.
  • Morphogenic regulation is crucial for C. albicans virulence.

Purpose of the Study:

  • To review current understanding of quorum sensing (QS) in C. albicans.
  • To explore the role of QS molecules in C. albicans virulence.
  • To investigate potential cross-kingdom interactions mediated by QS.

Main Methods:

  • Review of existing literature on C. albicans morphogenesis and QS.
  • Analysis of studies demonstrating cell-density-dependent morphogenic control.
  • Identification of known QS molecules affecting yeast-to-hyphal transition.

Main Results:

  • C. albicans exhibits cell-density-dependent morphogenesis, similar to bacterial QS.
  • Cell densities below 10^6 cells/mL favor hyphal formation, while higher densities maintain yeast form.
  • Three specific molecules have been identified as QS mediators in C. albicans.

Conclusions:

  • Cell density and QS play a significant role in regulating C. albicans morphology.
  • Understanding QS in C. albicans is key to addressing its virulence.
  • QS molecules may mediate interactions between C. albicans and other organisms.