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Updated: Jun 28, 2026
09:13
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Protein synthesis by platelets: historical and new perspectives
A S Weyrich1, H Schwertz, L W Kraiss
1Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA. andy.weyrich@hmbg.utah.edu
Journal of Thrombosis and Haemostasis : JTH
|November 6, 2008
Summary
Platelets synthesize proteins, a capability confirmed over decades. This protein synthesis changes with platelet activation and alters their function, impacting cellular responses.
Area of Science:
- Biochemistry
- Cell Biology
- Hematology
Background:
- Platelets, crucial for hemostasis, were historically considered primarily for their role in blood clotting.
- Early research in the late 1960s revealed platelets possess the machinery for protein synthesis.
Observation:
- Numerous independent studies over 30 years confirmed platelet protein synthesis.
- The pattern of protein synthesis in platelets is dynamic and responsive to cellular activation.
Findings:
- Recent research elucidated the mechanisms underlying platelet protein synthesis.
- Platelet protein synthesis directly modifies platelet phenotype and biological functions.
Implications:
- Understanding platelet protein synthesis offers new therapeutic targets for bleeding disorders and thrombosis.
- Future research will likely focus on the regulatory mechanisms and functional consequences of platelet-derived proteins.
Related Concept Videos
01:18Structure and Function of Platelets
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Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
01:22Formation of the Platelet Plug
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01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
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02:24Ribosome Profiling
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
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Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...