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A new cytotoxic guaianolide from Chrysanthemum boreale
Ki Hun Park1, Min Suk Yang, Moon Ki Park
1Division of Applied Life Science (BK21 program), EB-NCRC, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.
Fitoterapia
|November 6, 2008
Abstract:
A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested.

