Related Experiment Video
Updated: Jun 28, 2026
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Feasibility study for secure closure of natural orifice transluminal endoscopic surgery gastrotomies by using
Thomas Kratt1, Markus Küper, Frank Traub
1Clinic for General, Visceral and Transplantation Surgery, University Hospital of Tübingen, Germany.
Background:
The secure sealing of natural orifice transluminal endoscopic surgery (NOTES) approaches to the abdominal cavity is a problem that has not been solved. The feasibility of closing iatrogenic endoscopic GI-tract perforations by using a new over-the-scope clip was recently described.
Objective:
To demonstrate the feasibility of endoscopic closure of transgastric NOTES approaches with a novel clip system.
Design:
Acute nonsurvival animal study (porcine model; n = 9).
Interventions:
Transgastric approaches were performed by using a needle-knife and balloon dilation. After abdominopelvic exploration, the transgastric approaches were closed by using the OTSC clipping system with suction. The procedure was performed under laparoscopic visualization.
Results:
Gastrotomy lesions could primarily be closed in 8 cases. However, the laparoscopic control indicated that the clip adaptation of the wound margins was not completely airtight under maximum insufflation of the stomach in 4 of 9 cases.
Limitation:
Nonsurvival animal study.
Conclusions:
Sufficient closure of transgastric NOTES approaches is feasible when using the OTSC system. When considering our clinical experience, the OTSC system was shown to be an uncomplicated and secure sealing technique in human beings.
