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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
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It takes a (dysfunctional) village to raise a tumor
Karlyne M Reilly1, Terry Van Dyke
1Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA. kreilly@ncifcrf.gov
Abstract:
The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficient to block tumor growth.
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