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Updated: Jun 28, 2026
Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
Published on: March 17, 2014
Plasmacytoid dendritic cells and interferon levels are increased in lymphatic malformations
Jo Nadine Fleming1, Sirkka Liisa Hostikka, Eunice Y Chen
1Department of Pathology, University of Washington, Seattle, WA, USA.
Objective:
Describe the presence of plasmacytoid dendritic cells and type 1 interferon and the activation of interferon signaling pathway in lymphatic malformations.
Design:
Retrospective case series.
Materials:
Nineteen lymphatic malformations with matching clinical data were compared to control tissue (normal skin and lymph node).
Methods:
Paraffin-embedded tissue was evaluated for plasmacytoid dendritic cells, type 1 interferon, and type 1 interferon signaling with immunohistochemistry and RNA in situ hybridization. Staining results were compared with controls and correlated with clinical data with descriptive statistics and Mann-Whitney tests.
Results:
Lymphatic malformations had increased staining for plasmacytoid dendritic cells, interferons alpha and beta, and phosphorylated signal transducer and activator of transcription 1 compared with controls (P < 0.05). Significantly increased interferon beta staining was present in recurrent lymphatic malformation tissue compared with nonrecurrent lymphatic malformations.
Conclusion:
Lymphatic malformations have unusual ongoing local immune activation, possibly affecting recurrence.
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