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Preparation of iodine labeled recombinant human erythropoietin
H Kinoshita1, N Ohishi, A Okazaki
1Drug Metabolism Laboratory, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
Arzneimittel-Forschung
|May 1, 1991
Abstract:
125I-labelled recombinant human erythropoietin (125I-rh-EPO; CAS for EPO: 11096-26-7) was prepared by using iodo-gen (1,3,4,6-tetrachloro-3,6-diphenylglycouril), which showed a similar immunoreactivity to anti rh-EPO anti-rabbit serum and a similar pharmacokinetics with that of non-labeled rh-EPO.