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Correlation between insulin resistance and intracranial atherosclerosis in patients with ischemic stroke without

Hyun-Young Park1, Kyeong-Ho, Do-Sim Park

  • 1Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Jeonbuk, Korea. hypppark@hanmail.net

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|November 6, 2008
PubMed

Insights

Insulin resistance (IR) is linked to intracranial atherosclerosis in patients with acute ischemic stroke. This study found higher IR levels in patients with atherosclerosis, identifying IR as an independent predictor of intracranial disease.

Area of Science:

  • Neurology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Insulin resistance (IR) increases the risk of cardiovascular events, including stroke.
  • Atherosclerosis, a complication of IR, affects both cardiovascular and cerebrovascular systems.
  • Limited research exists on the connection between IR and intracranial atherosclerosis.

Purpose of the Study:

  • To investigate the association between insulin resistance and intracranial atherosclerosis in non-diabetic patients with acute ischemic stroke.

Main Methods:

  • 110 non-diabetic acute stroke patients underwent brain and cerebral angiography.
  • Patients were grouped by homeostasis model assessment of IR (HOMA-IR) tertiles.
  • Atherosclerosis was categorized as intracranial (IC) or extracranial (EC).

Main Results:

  • Higher HOMA-IR levels were observed in patients with IC or EC atherosclerosis compared to those without.
  • HOMA-IR showed a significant association with the location of atherosclerosis (IC + EC > IC > EC).
  • Multivariate analysis confirmed HOMA-IR as an independent predictor of IC atherosclerosis.

Conclusions:

  • Insulin resistance is associated with intracranial atherosclerosis in patients experiencing acute ischemic stroke without diabetes.
  • While the broader link between IR and stroke patterns in atherosclerosis needs further study, this finding highlights IR's role in IC disease.
Abstract

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