Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Cognition and Behavior01:23

Cognition and Behavior

Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Cognitivism01:17

Cognitivism

Cognitive psychology emerged as a significant field in the mid-20th century. It focused on understanding humans' internal mental processes. This approach emphasizes how people perceive, remember, think, and solve problems—elements critical to human cognition.
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process information is...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

PRMix: Primary Region Mix Augmentation and Benchmark Dataset for Precise Whole Mouse Brain Anatomical Delineation.

NeuroImage·2026
Same author

Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neurons.

Scientific reports·2026
Same author

Synapse types are spatially associated with regional hemodynamics in the mouse brain.

PLoS biology·2026
Same author

SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders.

Scientific reports·2025
Same author

SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies.

Wellcome open research·2025

Related Experiment Video

Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

G2Cdb: the Genes to Cognition database.

Mike D R Croning1, Michael C Marshall, Peter McLaren

  • 1Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Nucleic Acids Research
|November 6, 2008
PubMed
Summary

G2Cdb is a neuroscience database that links genes and proteins to their roles in synapse physiology and disease. It provides experimentally validated synapse proteome data, aiding research into brain disorders and synaptic function.

Related Experiment Videos

Last Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Neuroscience
  • Genetics
  • Proteomics

Background:

  • Neuroscience databases are crucial for understanding the nervous system across species.
  • Synapse proteins play a key role in nervous system physiology and disease.
  • Existing resources may not comprehensively link genetic, proteomic, and phenotypic data.

Purpose of the Study:

  • To develop G2Cdb, a neuroscience database focused on synapse proteins.
  • To integrate experimentally validated synapse proteome data with genetic and disease association information.
  • To provide a resource for studying synapse biology, physiology, and neurological disorders.

Main Methods:

  • Warehousing experimentally elucidated gene and protein sets from mammalian synapse preparations using proteomic mass spectroscopy.
  • Employing automated text-mining and expert curation to extract data from neurobiological studies on synaptic signaling, electrophysiology, and behavior in transgenic mice.
  • Surveying human genetics literature for gene mutations associated with neurological diseases.

Main Results:

  • G2Cdb provides experimentally validated synapse proteome datasets.
  • The database integrates information on genes, proteins, phenotypes in rodent models, and human disease associations.
  • Users can query gene/protein presence in brain signaling complexes, rodent phenotypes, and links to human diseases.

Conclusions:

  • G2Cdb offers a valuable resource for synapse biology research.
  • The database provides insights into brain diseases by linking genetic and protein information.
  • G2Cdb facilitates rapid querying for researchers investigating synaptic function and neurological disorders.