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Serum and middle ear immunoglobulins in suppurative otitis media

Akeem O Lasisi1, Olatubosun G Arinola, Rasheed A Bakare

  • 1Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria. akeemlasisi@gmail.com

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
|November 6, 2008
PubMed
Abstract

Insights

This study analyzed immunoglobulin levels in middle ear fluid (MEF) and serum of children with suppurative otitis media (SOM). Elevated IgG in MEF may indicate progression to chronic SOM, aiding in immunological assessment.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pediatrics

Background:

  • Suppurative otitis media (SOM) is increasingly prevalent.
  • Immunoglobulin levels in middle ear secretions (MES) during SOM remain largely undetermined.

Purpose of the Study:

  • To quantify and compare immunoglobulin G (IgG) and M (IgM) fractions in serum and MES of patients with acute SOM (ASOM) and chronic SOM (CSOM).
  • To establish a baseline for the immunological status of SOM patients.

Main Methods:

  • Enzyme-linked immunoassay was used to analyze serum and MES for IgG and IgM.
  • Subjects included pediatric patients diagnosed with ASOM and CSOM, alongside a control group.

Main Results:

  • Mean serum IgG levels were higher in CSOM than ASOM and controls. MES IgG levels were significantly elevated in both ASOM and CSOM.
  • Mean serum IgM levels were highest in ASOM, while MES IgM levels were higher in ASOM than CSOM.
  • Multivariate analysis indicated a significant correlation between serum and MES IgG levels in ASOM and CSOM patients.

Conclusions:

  • Monitoring serum and MES IgG in ASOM could serve as an index for predicting progression to chronicity.
  • This research provides valuable data on the immunological profile of patients with SOM.

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