Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Role of Amygdala in Memory

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

Physiology of Emotion

Physiology of Emotion

The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...

Coping Strategies: Emotion Focused

Coping Strategies: Emotion Focused

Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed to...

The Influence of Cognition on Affect

The Influence of Cognition on Affect

Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be interpreted as...

Facial Feedback Hypothesis

Facial Feedback Hypothesis

Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026

Same author

Familial Risk and Resilience Moderate the Association Between Intolerance of Uncertainty and Youth Suicidal Ideation.

Journal of clinical psychology·2026

Same author

Speech-Derived Digital Markers of Treatment Response and Improvement Trajectories in Pediatric Anxiety.

Research square·2026

Same author

Brain age prediction in generalized anxiety disorder using a convolutional neural network.

Translational psychiatry·2026

Same author

Symptom severity, neighborhood crime, and neural correlates of reappraisal in patients with major depression and social anxiety.

Psychological medicine·2026

Same author

Family Resilience and Mental and Physical Health Sequelae of Pediatric TBI in Youths.

JAMA network open·2026

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Amygdala-frontal connectivity during emotion regulation.

Sarah J Banks¹, Kamryn T Eddy, Mike Angstadt

¹Brain Imaging & Emotions Laboratory, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA.

Social Cognitive and Affective Neuroscience

|November 6, 2008

Summary

This summary is machine-generated.

Cognitive reappraisal uses frontal cortex activity to regulate amygdala responses, aiding emotion control. Stronger frontal-amygdala connectivity predicts better reduction of negative affect.

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Related Experiment Videos

Last Updated: Jun 28, 2026

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Area of Science:

Neuroscience
Cognitive Psychology
Affective Science

Background:

Emotion regulation involves modulating negative emotional responses.
Cognitive strategies like reappraisal are key to affect control.
Frontal cortical regions are implicated in regulating amygdala reactivity.

Purpose of the Study:

To investigate within-subject inter-regional connectivity between the amygdala and prefrontal cortex during affect regulation.
To determine if functional connectivity strength predicts the effectiveness of emotion regulation.

Main Methods:

Functional magnetic resonance imaging (fMRI) data were analyzed.
Psychophysiological interaction (PPI) analyses were employed.
Connectivity between frontal cortical areas and the amygdala was assessed during a reappraisal task.

Main Results:

Activity in specific frontal cortical areas (dorsolateral, dorsal medial, anterior cingulate, orbital) covaried with amygdala activity.
This functional connectivity was dependent on the reappraisal task.
Amygdala coupling strength with orbitofrontal cortex and dorsal medial prefrontal cortex predicted greater attenuation of negative affect.

Conclusions:

Functional connectivity within limbic-frontal circuitry is crucial for emotion regulation.
Specific frontal regions show task-dependent covariance with amygdala activity.
The strength of this connectivity influences the success of cognitive reappraisal in reducing negative affect.