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Related Experiment Videos

Hepatobiliary MR imaging: first human experience with MnDPDP.

K O Lim1, D D Stark, P T Leese

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.

Radiology
|January 1, 1991
PubMed
Summary

The first human MR imaging results show manganese(II)N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (MnDPDP) effectively enhances liver visualization. This hepatobiliary contrast agent provides dose-dependent signal enhancement and gallbladder visualization in healthy subjects.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Pharmacology

Background:

  • Hepatobiliary contrast agents are crucial for liver imaging.
  • Manganese(II)N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (MnDPDP) is a novel paramagnetic agent developed for hepatobiliary imaging.

Purpose of the Study:

  • To report the initial human magnetic resonance (MR) imaging findings for MnDPDP.
  • To evaluate contrast enhancement and visualization of normal liver structures using MnDPDP.

Main Methods:

  • Twelve healthy volunteers received MnDPDP at doses of 3, 10, or 15 mumol/kg.
  • Abdominal MR images were acquired at 1.5 T using a spin-echo sequence.
  • Imaging was performed for 30 minutes post-injection at 1-5 minute intervals.

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Main Results:

  • Significant liver parenchyma enhancement was observed within 1 minute, persisting for at least 30 minutes.
  • Visualization of MnDPDP clearance into the gallbladder occurred within 15 minutes.
  • Enhancement was dose-dependent, with 10 mumol/kg yielding 75%-100% liver signal enhancement at 10 minutes.

Conclusions:

  • MnDPDP demonstrates effective hepatobiliary contrast enhancement in human MR imaging.
  • The agent facilitates visualization of liver parenchyma and gallbladder, with dose-dependent effects.
  • MnDPDP shows promise as a specific contrast agent for hepatobiliary imaging.