Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Sample Handling01:02

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
¹H NMR Signal Integration: Overview00:58

¹H NMR Signal Integration: Overview

The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Descriptive Exploration of Features Among Infants With Prenatal Fentanyl Exposure in a Multisite Cohort of Maternal-Infant Dyads Affected by Opioid Use Disorder.

Journal of addiction medicine·2026
Same author

Human plasma proteomic profile of clonal hematopoiesis.

Nature communications·2025
Same author

Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study.

Circulation·2025
Same author

Influenza vaccination during early pregnancy and risk of major birth defects, US Birth Defects Study To Evaluate Pregnancy exposureS, 2014-2019.

Vaccine·2025
Same author

Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness.

medRxiv : the preprint server for health sciences·2025
Same author

United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus.

JACC. Advances·2025
Same journal

Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685-695 (10.1002/bdra.23517).

Birth defects research. Part A, Clinical and molecular teratology·2016
Same journal

Response to Dr. Kirby.

Birth defects research. Part A, Clinical and molecular teratology·2016
Same journal

Response to letter to the editor by Wise.

Birth defects research. Part A, Clinical and molecular teratology·2016
Same journal

Letter to the editor: Comments on venlafaxine paper by Laurent et al.

Birth defects research. Part A, Clinical and molecular teratology·2016
Same journal

Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011.

Birth defects research. Part A, Clinical and molecular teratology·2016
Same journal

Evaluation of the Western Australian Register of Developmental Anomalies: Thirty-five years of surveillance.

Birth defects research. Part A, Clinical and molecular teratology·2016
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

STFEEG-Tool: A Spatial-Temporal-Frequency EEG Analysis Tool for Motor Imagery Brain-Computer Interfaces
05:36

STFEEG-Tool: A Spatial-Temporal-Frequency EEG Analysis Tool for Motor Imagery Brain-Computer Interfaces

Published on: March 10, 2026

Fine-grained record integration and linkage tool.

Pawel Jurczyk1, James J Lu, Li Xiong

  • 1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30322, USA. pjurczy@emory.edu

Birth Defects Research. Part A, Clinical and Molecular Teratology
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

A new software tool, FRIL (fine-grained probabilistic record integration and linkage), improves birth defect surveillance by enabling efficient and accurate data linkage. This tool enhances data quality assessment for public health initiatives.

More Related Videos

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Dendrochronological Dating and Provenancing of String Instruments
10:26

Dendrochronological Dating and Provenancing of String Instruments

Published on: October 6, 2022

Related Experiment Videos

Last Updated: Jun 28, 2026

STFEEG-Tool: A Spatial-Temporal-Frequency EEG Analysis Tool for Motor Imagery Brain-Computer Interfaces
05:36

STFEEG-Tool: A Spatial-Temporal-Frequency EEG Analysis Tool for Motor Imagery Brain-Computer Interfaces

Published on: March 10, 2026

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Dendrochronological Dating and Provenancing of String Instruments
10:26

Dendrochronological Dating and Provenancing of String Instruments

Published on: October 6, 2022

Area of Science:

  • Public Health Informatics
  • Biostatistics
  • Software Engineering

Background:

  • Birth defect surveillance is crucial for monitoring population health.
  • Existing methods for linking vital records and surveillance data can be inefficient and lack objective quality assessment.
  • A robust record linkage tool is needed to improve the accuracy and efficiency of birth defect surveillance programs.

Purpose of the Study:

  • To develop and evaluate a novel software tool, FRIL, for probabilistic record linkage.
  • To enhance the accuracy, efficiency, and objective quality assessment of data linkages in birth defect surveillance.
  • To provide a user-friendly interface with tunable parameters and visualization tools for data linkage.

Main Methods:

  • Developed a Java-based probabilistic record linkage tool (FRIL).
  • Incorporated diverse record distance metrics, search strategies, and analysis capabilities.
  • Linked 1.25 million vital records with 12,700 birth defect surveillance records from the Metropolitan Atlanta Congenital Defects Program (MACDP) (1967-2006).

Main Results:

  • FRIL demonstrated superior efficiency compared to conventional algorithms for linking birth certificates and birth defect records.
  • Achieved high accuracy with 99% precision and 95% recall in data linkage.
  • Received positive user feedback, leading to ongoing development and adoption in other MACDP projects.

Conclusions:

  • FRIL provides accurate data linkages for birth defect surveillance programs.
  • The software facilitates objective assessment of linked data quality.
  • User-controlled, interactive tools like FRIL are valuable for improving public health surveillance systems.