Related Experiment Video

Updated: Jun 28, 2026

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
03:33

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology

Published on: May 23, 2025

Prevalence of infantile hypertrophic pyloric stenosis in Texas, 1999-2002

Jing Wang1, D Kim Waller, Lu-Yu Hwang

  • 1The University of Texas, Houston Health Science Center, School of Public Health, Houston, Texas 77030, USA.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|November 6, 2008
PubMed

Insights

Infantile hypertrophic pyloric stenosis (IHPS) is less common in female and Black infants. Foreign-born Hispanic and Asian infants showed significantly lower IHPS rates compared to White infants.

Area of Science:

  • Pediatric Surgery
  • Epidemiology
  • Public Health

Background:

  • The etiology of infantile hypertrophic pyloric stenosis (IHPS) remains largely unknown.
  • This study investigates IHPS prevalence concerning maternal nativity, ethnicity, and surgical timing.

Purpose of the Study:

  • To examine the association between maternal ethnicity and nativity and the risk of IHPS.
  • To determine if these risk factors influence the timing of pyloromyotomy.

Main Methods:

  • Utilized the Texas Birth Defects Registry for IHPS cases from 1999-2002.
  • Calculated crude and adjusted prevalence ratios (aPRs) using logistic regression.

Main Results:

  • IHPS was more prevalent in boys (aPR 4.21).
  • Lower IHPS rates were observed in Black infants, foreign-born Hispanics, and various Asian subgroups compared to Whites.
  • No significant difference in risk was found for US-born Asians or Hispanics, nor did risk vary with surgery timing.

Conclusions:

  • Confirmed lower IHPS rates in female and Black infants.
  • Significant decreases in IHPS rates were noted for foreign-born Hispanics and Asians, but not their US-born counterparts.
  • Potential explanations include differences in behavioral risk factors or case ascertainment across ethnic and nativity groups.
Abstract

More Related Videos

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis03:57

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis

Published on: July 8, 2025

Related Concept Videos

Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...