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Updated: Jun 28, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development
Sergei G Tevosian1, Nikolay L Manuylov
1Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. sergei.g.tevosian@dartmouth.edu
Abstract:
The mammalian embryonic gonad is a unique organ primordium in that it can adopt two different developmental fates-namely, differentiate as either a testis or an ovary-with dramatic consequences for an individual. While a molecular cascade culminating in testis development is well characterized, the ovarian pathways still remain enigmatic. The canonical Wnt/beta-catenin signaling implements a conserved mechanism of regulating gene expression that is integral to development of all metazoans. In this review, we summarize the recent evidence that suggests a central role for this signaling pathway in the development of the mammalian female.
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