Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensory-selective Sciatic Nerve Block with 2',6' Pipecolylxylidine in an Ovine Model.

Anesthesiology·2026
Same author

Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide: Erratum.

Anesthesiology·2026
Same author

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice.

Science translational medicine·2026
Same author

Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.

Nature communications·2026
Same author

Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2',6'-Pipecoloxylidide.

Angewandte Chemie (International ed. in English)·2026
Same author

Mineral-originated bioelectronics for inhibition via lithium electrochemistry.

Nature materials·2026

Related Experiment Video

Updated: Jun 28, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Three-dimensional conductive constructs for nerve regeneration.

Paul M George1, Rajiv Saigal, Michael W Lawlor

  • 1Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Journal of Biomedical Materials Research. Part A
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

Conductive polypyrrole tubes were fabricated and tested as nerve guides. These polymer guides successfully supported peripheral nerve regeneration in rats over an 8-week period.

More Related Videos

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Three-Dimensional Motor Nerve Organoid Generation
09:57

Three-Dimensional Motor Nerve Organoid Generation

Published on: September 24, 2020

Related Experiment Videos

Last Updated: Jun 28, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Three-Dimensional Motor Nerve Organoid Generation
09:57

Three-Dimensional Motor Nerve Organoid Generation

Published on: September 24, 2020

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Polymer Chemistry

Background:

  • Peripheral nerve injuries pose significant challenges to regeneration.
  • Current nerve regeneration strategies often require complex surgical interventions.
  • Conductive polymers offer unique properties for biomedical applications.

Purpose of the Study:

  • To develop and evaluate stand-alone conductive polymer tubes for peripheral nerve regeneration.
  • To assess the efficacy of polypyrrole nerve guides in promoting nerve repair.

Main Methods:

  • Fabrication of noncomposite polypyrrole (PPy) tubes via electrodeposition with varying inner diameters (25 microm to 1.6 mm).
  • Utilized oxidation for film growth and subsequent reduction for mechanical dissociation from electrode molds.
  • Implantation of PPy nerve guides into transected rat sciatic nerves.

Main Results:

  • Successfully fabricated stand-alone, conductive PPy tubes and multichannel tubes.
  • Demonstrated the ability of PPy tubes to support peripheral nerve regeneration.
  • Observed nerve regeneration over an 8-week experimental period in rat models.

Conclusions:

  • Conductive polypyrrole tubes are a viable and effective conduit for peripheral nerve regeneration.
  • The electrodeposition method allows for controlled fabrication of PPy nerve guides.
  • These findings highlight the potential of conductive polymers in advancing nerve repair therapies.