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Updated: Jun 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Optimization of cardiac resynchronization therapy

Amit Bhan1, Stamatis Kapetanakis, Mark J Monaghan

  • 1Department of Echocardiography, Kings College Hospital, Denmark Hill, London, UK.

Echocardiography (Mount Kisco, N.Y.)
|November 7, 2008
PubMed

Insights

Cardiac resynchronization therapy (CRT) benefits many patients with left ventricular (LV) systolic dysfunction. Research is ongoing to optimize CRT device settings, like atrioventricular (AV) and ventricular-to-ventricular (VV) delays, to improve patient outcomes.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac resynchronization therapy (CRT) is a standard treatment for left ventricular (LV) systolic dysfunction.
  • A significant portion of patients do not respond optimally to CRT, necessitating further research.

Purpose of the Study:

  • To investigate the impact of optimizing atrioventricular (AV) and ventricular-to-ventricular (VV) delays in CRT devices.
  • To explore methods for improving patient response to CRT through device parameter optimization.

Main Methods:

  • Review of contemporary CRT devices with adjustable AV and VV delays.
  • Analysis of existing evidence on the hemodynamic effects of optimizing these delays.
  • Assessment of current clinical practice regarding delay optimization.

Main Results:

  • Optimization of AV and VV delays can positively influence patient hemodynamics.
  • Multiple strategies exist for delay optimization, lacking widespread clinical consensus.
  • Current clinical practice for incorporating delay optimization into patient management is inconsistent.

Conclusions:

  • Further research is needed to establish standardized protocols for AV and VV delay optimization in CRT.
  • Optimizing device delays holds potential for improving CRT efficacy in non-responders.
  • Consensus on best practices for CRT delay optimization is crucial for widespread clinical adoption.

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