Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Accessory Structures of the Skin: Nails

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Desmosomes

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

Cardiovascular System Abnormal Findings I: Inspection and Palpation

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Associations of Glyphosate Exposure in Pregnancy with Preterm Birth: a Longitudinal Birth Cohort Study.

Environmental pollution (Barking, Essex : 1987)·2026

Same author

Evaluating the Effect of the EAT-Lancet Diet on Pemphigus Vulgaris Severity: Insights From a Cross-Sectional Study.

Health science reports·2026

Same author

Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.

Environmental health perspectives·2026

Same author

Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium.

Environmental health perspectives·2026

Same author

Air pollution and autism-like traits: Sensitive periods and joint effects of exposure to sources and constituents of fine particulate matter.

Environmental research·2026

Same author

Tofacitinib in Overlapping Autoimmune and Autoinflammatory Disorders: A Case Report of a Dual Graham-Little-Piccardi-Lasseur Syndrome and Hidradenitis Suppurativa.

Case reports in dermatology·2026

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Nail changes in pemphigus vulgaris.

Mohammadali Habibi¹, Hossein Mortazavi, Shervin Shadianloo

¹Department of Dermatology, Pemphigus Research Unit, Razi Hospital, Tehran University for Medical Sciences, Tehran, Iran.

International Journal of Dermatology

|November 7, 2008

Summary

Nail changes in pemphigus vulgaris (PV) are common, affecting over 30% of patients. These changes, like paronychia and onychomadesis, are linked to skin and periungual blisters, indicating disease severity.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Jun 28, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Dermatology
Autoimmune Blistering Diseases

Background:

Pemphigus vulgaris (PV) is an autoimmune condition with unclear nail manifestation patterns.
The frequency and specific types of nail changes in PV require further elucidation.

Purpose of the Study:

To investigate the prevalence and characteristics of nail alterations in patients with pemphigus vulgaris.
To determine the correlation between nail changes and the extent of skin and periungual bullae in PV patients.

Main Methods:

A cohort of 79 patients diagnosed with pemphigus vulgaris was studied.
Clinical assessment of nails was performed, with microscopic examination and fungal cultures for abnormal nails.

Main Results:

Nail changes were observed in 31.6% of the 79 PV patients.
Paronychia and onychomadesis were the most frequent nail findings; onychomycosis was rare.
Nail alterations were significantly more common on fingers with periungual bullae and correlated with more extensive skin bullae and longer disease duration.

Conclusions:

Nail changes are a frequent clinical feature in pemphigus vulgaris.
The presence and number of skin bullae and periungual bullae are associated with the occurrence of nail changes in PV.