Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Overview of Systemic Arteries

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Favourable course of cancer of unknown primary].

Nederlands tijdschrift voor geneeskunde·2019

Same author

Prospective Follow-Up of Cortical Interruptions, Bone Density, and Micro-structure Detected on HR-pQCT: A Study in Patients with Rheumatoid Arthritis and Healthy Subjects.

Calcified tissue international·2019

Same author

An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; a reproducibility study.

BMC medical imaging·2018

Same author

Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography: a study in finger joints of patients with rheumatoid arthritis and healthy subjects.

Scandinavian journal of rheumatology·2018

Same author

The Prevalence of Latent Tuberculosis and Hepatitis B After Systematic Screening of Patients Prescribed Biological Therapy in a Low-endemic Area.

Journal of Crohn's & colitis·2017

Same author

Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study.

Scientific reports·2017

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Nodular vasculitis in systemic lupus erythematosus.

Annet Westers-Attema¹, A van Tubergen, H Plasschaert

¹Department of Dermatology, University Hospital Maastricht, University Hospital Maastricht, The Netherlands. awes@sder.azm.nl

International Journal of Dermatology

|November 15, 2008

Summary

This case study highlights a rare presentation of systemic lupus erythematosus (SLE) with type II cryoglobulinemia and nodular vasculitis, emphasizing distinct histopathological findings in subcutaneous lesions.

Related Experiment Videos

Last Updated: Jun 28, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Rheumatology
Dermatology
Pathology

Background:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
Vasculitis, inflammation of blood vessels, can occur in SLE and is often characterized by leukocytoclastic vasculitis of superficial vessels.
Type II cryoglobulinemia is a condition associated with certain autoimmune disorders, potentially leading to vascular complications.

Observation:

A 42-year-old male presented with a complex constellation of symptoms including fever, photosensitivity, arthritis, oral ulcers, alopecia, and painful subcutaneous nodes.
Initial clinical suspicion included systemic lupus erythematosus (SLE) and type II cryoglobulinemia.
Histopathological examination of subcutaneous nodes revealed leukocytoclastic vasculitis with extensive involvement of dermal and subdermal small and medium-sized vessels, indicative of nodular vasculitis.

Findings:

The patient was diagnosed with systemic lupus erythematosus (SLE), type II cryoglobulinemia, and nodular vasculitis.
Unlike typical presentations of vasculitis in SLE or cryoglobulinemia which often manifest as palpable purpura due to superficial vessel involvement, this patient exhibited nodular vasculitis.
The histopathology demonstrated a more profound vasculitic process extending into deeper dermal and subdermal layers, resulting in the characteristic nodular lesions.

Implications:

This case underscores the importance of thorough histopathological evaluation in diagnosing complex vasculitic syndromes.
Recognizing nodular vasculitis as a manifestation of SLE and cryoglobulinemia expands the spectrum of cutaneous involvement in these conditions.
Understanding these distinct pathological findings is crucial for accurate diagnosis and tailored patient management.