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[Clonidine in the treatment of cancer pain]
Jan Bjørn Nielsen1, Per Sjøgren
1Palliativt Team, Regionshospitalet Herning, DK-7400 Herning. jbjn@dadlnet.dk
Unlabelled:
Clonidine is an alpha2-adrenergic agonist with analgetic properties. Due to its side-effects, the drug is administered via the epidural or spinal route. A literature search yielded nine controlled studies on clonidine as a supplemental drug in the epidural or spinal treatment of cancer pain. These studies were systematically reviewed to evaluate the evidence of efficacy in patients with cancer pain.
Conclusion:
Despite weak evidence, clonidine may be a useful adjunct in epidural or spinal morphine therapy of cancer pain.
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