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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Mouse phenome database.

Stephen C Grubb1, Terry P Maddatu, Carol J Bult

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Nucleic Acids Research
|November 7, 2008
PubMed
Summary
This summary is machine-generated.

The Mouse Phenome Database (MPD) offers a centralized resource for mouse phenotypic and genotypic data, aiding researchers in selecting optimal strains for various studies and accelerating scientific discovery.

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Area of Science:

  • Genomics
  • Phenomics
  • Bioinformatics

Background:

  • The Mouse Phenome Database (MPD) is a vital open-source, web-based repository.
  • It houses phenotypic and genotypic data for inbred mouse strains and their derivatives.
  • MPD serves as a platform for data query, analysis, and in silico hypothesis testing.

Purpose of the Study:

  • To provide researchers with electronic access to centralized mouse strain data.
  • To facilitate the selection of optimal mouse strains for systems-based research.
  • To accelerate research by enabling access to existing phenotype data, reducing the need for re-characterization.

Main Methods:

  • Compilation of approximately 1400 phenotypic measurements from global research teams.
  • Inclusion of phenotypes relevant to human health, such as cancer, aging, and infectious diseases.
  • Development of new tools and features, including an interactive Tool Demo.

Main Results:

  • MPD contains extensive phenotypic data relevant to human health and disease.
  • Electronic access to data enables efficient strain selection for physiological studies, drug testing, and disease modeling.
  • Recent updates include expanded community-contributed data and enhanced analytical tools.

Conclusions:

  • MPD significantly accelerates research by leveraging existing community resources and facilitating informed strain selection.
  • The database supports diverse research applications, from basic physiology to complex trait analysis.
  • MPD continues to evolve with new data and features to support the scientific community.