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A case report of malignant pleural mesothelioma with long-term disease control after chemotherapy

T Umsawasdi¹, H M Dhingra, C Charnsangavej

¹Department of Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

|January 1, 1991

Abstract:

Long duration of responses to chemotherapy in patients with malignant pleural mesothelioma (MPM) is rare. The authors report a patient with inoperable MPM who achieved complete remission with combination chemotherapy of cyclophosphamide, doxorubicin, and cisplatin. 5-fluorouracil and mitomycin C (FM) induced another remission after recurrence of the tumor. Retreatment with FM after chemotherapy had been stopped for 20 months yielded another continuing response. The overall tumor-control time is more than 4 years. Literature reviews and the authors' results suggest that MPM may be a chemosensitive tumor in some patients. Additional evaluations of CAP, FM, and methotrexate combination regimens in this disease should be considered.

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