Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testis cancer. Ichthyosis constitutes a significant risk factor.

G Lykkesfeldt1, P Bennett, A E Lykkesfeldt

  • 1Department of Obstetrics and Gynecology, Hvidovre Hospital University of Copenhagen, Denmark.

Cancer
|February 1, 1991
PubMed
Summary

Men with ichthyosis have a higher risk of developing testicular cancer. Researchers investigated the connection, finding distinct subtypes of ichthyosis and analyzing hormone levels in affected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.

Oncogene·2019
Same author

Correction: Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.

Oncogene·2018
Same author

Football training over 5 years is associated with preserved femoral bone mineral density in men with prostate cancer.

Scandinavian journal of medicine & science in sports·2018
Same author

The "Football is Medicine" platform-scientific evidence, large-scale implementation of evidence-based concepts and future perspectives.

Scandinavian journal of medicine & science in sports·2018
Same author

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer.

Oncogene·2017
Same author

Muscle satellite cell content and mRNA signaling in germ cell cancer patients - effects of chemotherapy and resistance training.

Acta oncologica (Stockholm, Sweden)·2016

Area of Science:

  • Genetics and Endocrinology
  • Dermatology
  • Oncology

Background:

  • Testis cancer and ichthyosis are rare diseases.
  • A study observed an unusual number of individuals with both conditions.
  • This suggests a potential link between ichthyosis and testicular cancer risk.

Purpose of the Study:

  • To investigate the relationship between ichthyosis subtypes and testicular cancer.
  • To analyze serum hormone levels in patients with testicular cancer and ichthyosis.
  • To explore potential etiological factors connecting these rare diseases.

Main Methods:

  • Clinical assessment of ichthyosis subtypes.
  • Measurement of steroid sulfatase (STS) activity in leukocytes.
  • Analysis of serum hormone levels including androgens, estrogens, FSH, and LH.

Related Experiment Videos

Main Results:

  • Three patients with ichthyosis and testicular cancer had recessive X-linked ichthyosis (no STS activity).
  • Three patients had autosomal dominant ichthyosis (normal STS activity).
  • Patients with testicular cancer (with or without ichthyosis) showed altered levels of 4-androstenedione, FSH, LH, estrone, and estrone sulfate.

Conclusions:

  • The study identified distinct ichthyosis subtypes in patients with testicular cancer.
  • Hormonal profiles in patients with ichthyosis and testicular cancer showed some alterations, but no definitive cause was identified.
  • The underlying reasons for the increased risk of testicular cancer in men with ichthyosis remain unclear.