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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Glial Cells01:04

Glial Cells

Overview
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Related Experiment Video

Updated: Jun 28, 2026

Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc
09:12

Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc

Published on: July 9, 2009

Glial chain migration requires pioneer cells.

Benoît Aigouy1, Léa Lepelletier, Angela Giangrande

  • 1Centre National de la Recherche Scientifique, Institut de Génétique et Biologie Moléculaire et Cellulaire, Université Louis Pasteur, Illkirch, Communauté Urbaine de Strasbourg, France.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 7, 2008
PubMed
Summary

Pioneer glial cells guide nerve development in Drosophila. These cells, through direct contact and interactions, ensure coordinated migration and sheath formation, offering insights into vertebrate nervous system development.

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Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc
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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
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Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Glial cell migration is crucial for nervous system formation but poorly understood.
  • Difficulty in manipulating identified cells hinders research into glial migration dynamics.

Purpose of the Study:

  • To identify the cellular mechanisms underlying glial chain migration in vivo.
  • To investigate the role of specific glial cells in guiding migratory chains.

Main Methods:

  • Confocal time-lapse microscopy in whole Drosophila.
  • Cell ablation techniques in vivo.

Main Results:

  • Identified a discrete population of pioneer glial cells in Drosophila.
  • Pioneer cells establish direct, stable cytoplasmic connections with follower cells.
  • Homotypic interactions at the migratory chain's tip facilitate coordinated movement and nerve sheath formation.

Conclusions:

  • Pioneer glial cells are essential for directing collective glial migration.
  • In vivo findings provide a cellular basis for understanding vertebrate glial migration in health and disease.