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Updated: Jun 28, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides
Russel J Reiter1, Ahmet Korkmaz, Sergio D Paredes
1Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas, USA. reiter@uthscsa.edu
Abstract:
The purpose of this brief review is to introduce the reader to the vast amount of published literature related to the free radical scavenging and antioxidative activity of melatonin. However, this review summarizes only a few of the many conditions in which melatonin has been found to be protective against oxidative/nitrosative damage. Melatonin ameliorates the extensive free radical-mediated damage that ensues following exposure to a wide variety of environmental insults. Concisely reviewed in this report are the protective effects of melatonin against toxic prescription drugs, neural toxins, herbicides and metals. The findings have clear implications for the utility of melatonin in toxicology.
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