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The GTPase superfamily: conserved structure and molecular mechanism
H R Bourne1, D A Sanders, F McCormick
1Department of Pharmacology, University of California, San Francisco 94143-0450.
Nature
|January 10, 1991
Abstract:
GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.