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Serum prolactin levels in HLA-B27-associated uveitis
H Proenca1, C Ferreira, M Miranda
1Department of Ophthalmology, Visual Sciences Research Centre, University of Lisbon, Lisbon - Portugal. helenproenca@hotmail.com
European Journal of Ophthalmology
|November 7, 2008
Summary
Serum prolactin levels are significantly elevated in patients with Human Leukocyte Antigen B27 (HLA-B27)-associated uveitis, particularly those with associated arthritic conditions. This elevation may play a role in the disease
Area of Science:
- Ophthalmology
- Immunology
- Endocrinology
Background:
- Human Leukocyte Antigen B27 (HLA-B27) is strongly associated with anterior uveitis.
- The role of endocrine factors, such as prolactin, in HLA-B27-associated uveitis is not well understood.
Purpose of the Study:
- To investigate basal serum prolactin levels in patients diagnosed with HLA-B27-associated uveitis.
- To compare prolactin levels between patients and healthy controls.
Main Methods:
- A prospective, nonrandomized comparative study included 33 patients with HLA-B27-associated uveitis and 30 healthy controls.
- Serum prolactin levels were measured using electrochemiluminescence immunoassay.
- Data on age, systemic disease, treatment, and uveitis activity were collected.
Main Results:
- Patients with HLA-B27-associated uveitis exhibited significantly higher serum prolactin levels (mean=15.84 ng/mL) compared to controls (mean=11.50 ng/mL) (p=0.026).
- Elevated prolactin levels were also observed in subgroups with arthritic disease (mean=17.21 ng/mL) and ankylosing spondylitis (mean=17.65 ng/mL).
- Higher prolactin levels correlated with autoimmune features but not with systemic treatment or uveitis disease activity.
Conclusions:
- Elevated serum prolactin may be implicated in the pathogenesis of HLA-B27-associated uveitis and its related arthritic subgroups.
- Serum prolactin levels do not appear to correlate with disease activity in this patient cohort.
