Related Experiment Video
Updated: Jun 28, 2026
10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
[Human microRNA in norm and pathology]
Molekuliarnaia Biologiia
|November 8, 2008
Summary
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. Dysregulation of these small RNAs is implicated in various diseases, particularly affecting muscle, immune, and nervous systems.
Area of Science:
- Molecular Biology
- Genetics
- Post-transcriptional Regulation
Context:
- MicroRNAs (miRNAs) are key regulators of gene expression at the post-transcriptional level.
- They function by binding to target RNA, suppressing translation or inducing mRNA degradation.
- miRNAs are crucial for gene expression programming during embryonic development and adult cell function.
Purpose:
- To review the specific features of miRNA-mediated gene expression regulation.
- To discuss the role of miRNAs in the normal and pathological development of major organ systems.
- To highlight the involvement of miRNAs in neurodegenerative and mental disorders.
Summary:
- miRNAs control gene expression by targeting mRNA, impacting cellular processes like proliferation, differentiation, and apoptosis.
- Alterations in miRNA expression profiles are significant in disease development, comparable to protein structural variations.
- This review focuses on miRNA roles in muscle, immune, and nervous system development and pathology, including neurological and psychiatric conditions.
Impact:
- Understanding miRNA function is vital for comprehending normal biological processes and disease pathogenesis.
- miRNA dysregulation is linked to a spectrum of common diseases.
- Evidence supports miRNA involvement in neurodegenerative and mental health disorders, suggesting potential therapeutic targets.
More Related Videos
09:06MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
08:22Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
Published on: September 15, 2018
Related Concept Videos
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...