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Related Experiment Video

Updated: Jun 28, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Technical approach to iliac crest biopsy.

Joel D Hernandez1, Katherine Wesseling, Renata Pereira

  • 1Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, A2-331, MDCC, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Clinical Journal of the American Society of Nephrology : CJASN
|November 15, 2008
PubMed
Summary

Bone biopsy and histomorphometry are crucial for diagnosing chronic kidney disease-mineral and bone disorder. This review highlights their safety and importance in understanding skeletal issues when biochemical markers fall short.

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Area of Science:

  • Nephrology
  • Pathology
  • Orthopedics

Background:

  • Bone histomorphometry is the gold standard for evaluating renal osteodystrophy.
  • Renal osteodystrophy is now defined as chronic kidney disease-mineral and bone disorder (CKD-MBD).
  • Bone biopsy remains a vital diagnostic tool for skeletal abnormalities in CKD patients.

Purpose of the Study:

  • To review the clinical indications for bone biopsy in CKD-MBD.
  • To discuss the preparation, instrumentation, and potential complications of iliac crest bone biopsy.
  • To emphasize the diagnostic value of bone histomorphometry due to limitations of biochemical markers.

Main Methods:

  • Review of literature on bone biopsy and histomorphometry in CKD-MBD.
  • Discussion of the safety and minimal morbidity associated with iliac crest bone biopsy.

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Last Updated: Jun 28, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
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Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
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Published on: March 4, 2016

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  • Analysis of the diagnostic utility of bone histomorphometry versus biochemical markers.

    • Main Results:

    • Iliac crest bone biopsy is a safe procedure with minimal complications.
    • Current biochemical markers are insufficient for accurately assessing bone turnover, volume, and mineralization in CKD-MBD.
    • Bone biopsy provides a direct and comprehensive evaluation of skeletal abnormalities.

    Conclusions:

    • Bone biopsy and histomorphometry are essential for accurate diagnosis and management of CKD-MBD.
    • Increased utilization of bone biopsy can enhance understanding of bone and mineral disorders in CKD.
    • This diagnostic approach is critical for improving patient outcomes in chronic kidney disease.