Looking back at pediatrics to move forward in obstetrics
Neal Halfon1, Helen DuPlessis, Emily Barrett
1David Geffen School of Medicine, UCLA School of Public Health, USA. nhalfon@ucla.edu
Current Opinion in Obstetrics & Gynecology
|November 8, 2008
Summary
The Life Course Health Development (LCHD) model offers a framework to improve women's reproductive health by integrating early life experiences into healthcare. This approach can enhance obstetric care and optimize women's reproductive readiness.
Area of Science:
- Reproductive Health
- Public Health
- Systems Science
Background:
- Current obstetrical care systems require reevaluation.
- The Life Course Health Development (LCHD) model provides a framework for understanding lifelong health.
- Integrating LCHD principles can improve care for women of childbearing age.
Purpose of the Study:
- To assess the current state of obstetrical care.
- To discuss the implications of the LCHD model for women's healthcare systems.
- To identify strategies from child health systems for adaptation to women's health.
Main Methods:
- Literature review and synthesis of evidence on the LCHD model.
- Analysis of existing child health programs for transferable strategies.
- Conceptualization of a reengineered obstetrics and women's healthcare system.
Main Results:
- The LCHD model integrates developmental origins of health and disease (DOHaD) evidence.
- Knowledge of early life influences can inform redesign of healthcare delivery.
- The child health system demonstrates successful implementation of evidence-based programs to promote health and prevent risk.
Conclusions:
- Obstetricians and public health researchers are adopting the LCHD model.
- The LCHD model can reconceptualize health trajectories and improve reproductive outcomes.
- Recommendations are provided for reengineering obstetrics and women's healthcare using the LCHD model to optimize reproductive readiness.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
ATP Driven Pumps I: An Overview
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
ATP Driven Pumps II: P-type Pumps
The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
Standards of Care II
Nurses bear specific legal responsibilities under several federal statutes, including:

