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Treatment-related myelodysplastic syndrome after temozolomide use in a child: first report
Christelle Dufour1, Lydie Da Costa, Nathalie Auger
1Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, 39, rue Camille Desmoulins, Villejuif cedex 94805, France. dufour@igr.fr
Abstract:
Temozolomide is an effective alkylating agent that is increasingly used for the treatment of pediatric brain tumors. Secondary, or treatment-related, myelodysplasia is a life-threatening complication of alkylating chemotherapy and has been reported in children with brain tumors after treatments other than temozolomide. We describe for the first time a case of temozolomide-related myelodysplasia in a child.
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