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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: Jun 28, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Stem cell therapy in stroke.

F Locatelli1, A Bersano, E Ballabio

  • 1IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.

Cellular and Molecular Life Sciences : CMLS
|November 8, 2008
PubMed
Summary
This summary is machine-generated.

Cell transplantation shows promise for treating ischemic stroke by improving function. While animal studies are positive, further research is needed to address challenges for human application.

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Last Updated: Jun 28, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • Ischemic stroke causes non-selective neural degeneration affecting various cell types.
  • Cell transplantation is being investigated as a potential therapy for stroke recovery.
  • Animal studies suggest transplanted cells survive and improve function post-stroke.

Purpose of the Study:

  • To evaluate the therapeutic potential of cell transplantation for ischemic stroke.
  • To understand the mechanisms underlying functional improvement after cell transplantation.
  • To assess the feasibility and challenges of stem cell therapy in human stroke patients.

Main Methods:

  • Review of animal studies on cell transplantation following ischemic stroke.
  • Analysis of proposed mechanisms, including trophic factor release and endogenous repair.
  • Examination of initial human clinical studies on stem cell therapy for stroke.

Main Results:

  • Animal models demonstrate cell survival and functional recovery after transplantation.
  • Trophic factor release is a key proposed mechanism, promoting neurogenesis and angiogenesis.
  • Initial human studies suggest technical feasibility but highlight remaining issues.

Conclusions:

  • Cell transplantation holds therapeutic potential for ischemic stroke, supported by preclinical data.
  • Mechanisms involve promoting endogenous repair and reducing cell death.
  • Further investigation and resolution of challenges are crucial for successful human application of stem cell therapy.