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Updated: Jun 28, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective

Emily O Dumas1, Gary M Pollack

  • 1Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, The University of North Carolina at Chapel Hill, CB #7360, Kerr Hall 2311, Chapel Hill, NC 27599-7360, USA. emily.olson@abbott.com

The AAPS Journal
|November 8, 2008
PubMed

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