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10:03
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
Meningococcal tetravalent conjugate vaccine
1University of Louisville School of Medicine, Division of Pediatric Infectious Diseases, 571 S Floyd Street, Suite 321, Louisville, KY 40202, USA. mjsmit22@louisville.edu
Expert Opinion on Biological Therapy
|November 8, 2008
Summary
The new meningococcal conjugate vaccine (MCV4) offers comparable safety and immunogenicity to older vaccines, with potentially longer-lasting protection against meningococcal disease.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Neisseria meningitidis is a significant global cause of meningitis and sepsis.
- A tetravalent meningococcal polysaccharide vaccine was available in the US since 1981 for specific populations.
- The tetravalent meningococcal conjugate vaccine (MCV4) was approved in 2005 for routine US use.
Purpose of the Study:
- To evaluate the immunogenicity and safety of MCV4.
- To predict the clinical effectiveness of MCV4 by analyzing data from other conjugate vaccine programs.
Main Methods:
- Systematic review of published controlled studies on MCV4 immunogenicity, safety, and cost-effectiveness.
- Analysis of publicly available clinical trial data.
- Review of Advisory Committee on Immunization Practices (ACIP) guidelines.
Main Results:
- MCV4 demonstrates similar safety and immunogenicity profiles to the previous polysaccharide vaccine.
- MCV4 appears to offer extended protection duration against meningococcal disease.
Conclusions:
- MCV4 is a safe and effective vaccine for meningococcal disease prevention.
- Further long-term studies are ongoing to determine MCV4's population-level effectiveness.
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