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Clinical recovery in first-episode psychosis
Lex Wunderink1, Sjoerd Sytema, Fokko J Nienhuis
1University Medical Center Groningen, University Psychiatric Center (5.21), University of Groningen, 9700 RB Groningen, The Netherlands. a.wunderink@med.umcg.nl
Introduction:
Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission.
Method:
In a sample of first-episode patients (N = 125), symptomatic and functional remission during the last 9 months of a 2-year follow-up period were examined, as well as recovery and its predictors.
Results:
Half the patients (52.0%) showed symptomatic remission and a quarter (26.4%) functional remission, while one-fifth (19.2%) met both criteria sets and were considered recovered. Recovery was significantly associated with short duration of untreated psychosis and better baseline functioning.
Conclusion:
Most functionally remitted patients were also symptomatically remitted, while a minority of symptomatically remitted patients were also functionally remitted. Treatment delay may affect chance of recovery.
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