Related Experiment Video
Updated: Jun 28, 2026

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
[Topiramate augmentation in treatment-resistant obsessive-compulsive disorder]
D J Vinkers1, N J A van der Wee
1Leids Universitair Medisch Centrum, afdeling Psychiatrie, Postbus 9600, 2300 RC Leiden. d.j.vinkers@lumc.nl
Abstract:
A 45-year-old patient with a medication-resistant obsessive-compulsive disorder was treated successfully by topiramate augmentation. Obsessive-compulsive disorder is associated neurobiologically with overactivation of the cortico-striato-thalamo-cortical circuit. Because the neurotransmitter glutamate plays an important role in this circuit, medication that has glutamate antagonism, such as the antiepileptic drug topiramate, may reduce the symptoms of obsessive-compulsive disorder. Further study is needed to find out whether topiramate augmentation is more effective than placebos in patients with a medication-resistant obsessive-compulsive disorder.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Obsessive-Compulsive Disorder
Antidepressant Drugs: MAOIs and Other Agents
Electroconvulsive Therapy
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Drug Therapy
Antianxiety Medications
