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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jun 28, 2026

Viral Nanoparticles for In vivo Tumor Imaging
14:04

Viral Nanoparticles for In vivo Tumor Imaging

Published on: November 16, 2012

Imaging virus-associated cancer.

De-Xue Fu1, Catherine A Foss, Sridhar Nimmagadda

  • 1Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

Current Pharmaceutical Design
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Molecular imaging combined with genetics aids cancer therapy. Gammaherpesviruses can be used for in vivo imaging and treatment, with techniques ready for clinical use.

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Last Updated: Jun 28, 2026

Viral Nanoparticles for In vivo Tumor Imaging
14:04

Viral Nanoparticles for In vivo Tumor Imaging

Published on: November 16, 2012

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
10:56

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Area of Science:

  • Oncology
  • Molecular Genetics
  • Medical Imaging

Background:

  • Cancer is a significant and increasing global health challenge.
  • Advances in understanding cancer genetics and molecular pathways are crucial.
  • Molecular imaging offers potential for patient selection and early treatment response detection.

Purpose of the Study:

  • To review the application of molecular-genetic imaging in tumor-associated viral infections.
  • To explore the use of gammaherpesviruses for in vivo imaging and therapy.
  • To highlight the clinical translatability of these advanced techniques.

Main Methods:

  • Integration of molecular genetics with advanced imaging technologies.
  • Utilizing gammaherpesviruses for gene expression enabling imaging and therapy.
  • Investigating pharmacologic stimulation for gene expression.

Main Results:

  • Molecular imaging can guide targeted cancer therapy and monitor treatment efficacy.
  • Gammaherpesviruses can be engineered to express imaging and therapeutic genes in vivo.
  • The discussed techniques show promise for clinical application.

Conclusions:

  • The synergy between molecular genetics and imaging is advancing cancer research and treatment.
  • Gammaherpesvirus-based molecular imaging presents a viable strategy for cancer management.
  • These innovative approaches are poised for translation into clinical practice.