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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 28, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Neutrophil proteome: lessons from different standpoints.

C F M Morris1, M S Castro, W Fontes

  • 1Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, Brazil.

Protein and Peptide Letters
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

This review traces the evolution of neutrophil biology research, highlighting the shift from basic biochemistry to high-throughput molecular methods and integrated life sciences like genomics.

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Last Updated: Jun 28, 2026

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Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
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Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

Area of Science:

  • Immunology and Cell Biology
  • Hematology

Background:

  • Neutrophils are critical immune cells involved in host defense.
  • Understanding neutrophil biology has evolved significantly over time.
  • Early research relied on fundamental biochemical approaches.

Purpose of the Study:

  • To provide a historical overview of key advancements in neutrophil biology research.
  • To highlight the impact of technological innovations on the field.
  • To discuss current trends and challenges in neutrophil research.

Main Methods:

  • Review of historical scientific literature.
  • Analysis of the progression of research methodologies.
  • Integration of findings from proteomics, genomics, lipidomics, and systems biology.

Main Results:

  • Demonstration of a timeline of major discoveries in neutrophil biology.
  • Emphasis on the transition from elementary biochemical studies to high-throughput molecular techniques.
  • Integration of neutrophil research with broader life sciences disciplines.

Conclusions:

  • Neutrophil research has advanced through technological innovation, particularly high-throughput methods.
  • Modern neutrophil studies benefit from integration with genomics, lipidomics, and systems biology.
  • Despite progress, challenges remain in fully elucidating neutrophil biology.