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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Physiological Barriers01:25

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...

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Related Experiment Video

Updated: Jun 28, 2026

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
13:34

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Published on: April 16, 2019

Brain permeable nanoparticles.

Dimple Chopra1, Monica Gulati, Vikrant Saluja

  • 1Department of Pharmaceutical Sciences, Punjabi University, Patiala, India. dimplechopra24@yahoo.co.in

Recent Patents on CNS Drug Discovery
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Nanoparticles offer a promising solution for delivering neurotherapeutics across the blood-brain barrier (BBB). This approach enhances drug efficacy and reduces toxicity for treating severe brain diseases.

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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

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Area of Science:

  • Neuroscience
  • Biotechnology
  • Materials Science

Background:

  • The brain's inaccessibility due to the blood-brain barrier (BBB) hinders neurotherapeutics delivery.
  • Effective treatment for brain diseases like cancer, Alzheimer's, and epilepsy remains a challenge.
  • Nanoparticles offer a novel drug delivery system to overcome BBB limitations.

Purpose of the Study:

  • To explore nanoparticle-based strategies for brain drug delivery.
  • To review methods for designing and delivering brain-targeted nanoparticles.
  • To survey patents involving nanoparticles for neurotherapeutics and neurodiagnostics.

Main Methods:

  • Utilizing polymeric nanoparticles as colloidal drug delivery systems.
  • Encapsulating, dissolving, or attaching active principles to nanoparticles.
  • Coating nanoparticles with surfactants to enhance brain drug concentration.

Main Results:

  • Brain-targeted nanoparticles improve therapeutic efficacy and reduce drug toxicity.
  • Surfactant-coated nanoparticles facilitate higher drug concentrations in the brain.
  • Various nanoparticle design and delivery approaches are presented.

Conclusions:

  • Nanoparticle-based drug delivery is a viable strategy to overcome the BBB.
  • This approach holds significant potential for treating neurological disorders.
  • Patented technologies highlight the growing interest in nanoparticles for brain therapies.