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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

[Effect of perindopril on cognitive functions in young and middle aged patients with hypertensive disease]

S A Smakotina, O A Trubnikova, Iu A Anan'ko

    Kardiologiia
    |November 11, 2008
    PubMed

    Insights

    Perindopril effectively treats high blood pressure (hypertensive disease) and improves cognitive function in patients. Its benefits, particularly for cognitive aspects, were more significant in individuals over 44 years old.

    Area of Science:

    • Cardiology
    • Neurology
    • Pharmacology

    Background:

    • Hypertensive disease (HD) is associated with cognitive abnormalities.
    • Elevated arterial pressure (AP) requires effective management strategies.

    Purpose of the Study:

    • To evaluate the efficacy of perindopril in treating hypertensive disease (HD) and associated cognitive dysfunction.
    • To assess the impact of perindopril on cognitive functions in patients with stage I and II HD.

    Main Methods:

    • A study involving 40 men aged 26-59 years with stage I and II hypertensive disease.
    • Therapy focused on the angiotensin converting enzyme inhibitor perindopril.
    • Assessment of arterial pressure (AP) and cognitive function parameters.

    Main Results:

    • Perindopril effectively corrected elevated arterial pressure (AP) in patients with hypertensive disease (HD).
    • Therapy with perindopril demonstrated favorable effects on cognitive abnormalities associated with HD.
    • The therapeutic effect was more pronounced in patients older than 44 years, linked to achieving target AP values.

    Conclusions:

    • Perindopril is an effective and safe hypotensive preparation for managing hypertensive disease (HD).
    • Perindopril exhibits cerebroprotective effects, improving cognitive functions in patients with hypertensive disease.
    • Target AP achievement is crucial for the therapeutic benefits of perindopril on cognitive parameters.

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