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Related Concept Videos

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
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Updated: Jun 28, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Addiction and cognitive functions.

Saturnino Spiga1, Alessandra Lintas, Marco Diana

  • 1Department of Animal Biology and Ecology, University of Cagliari, 0125 Cagliari, Italy.

Annals of the New York Academy of Sciences
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Drug addiction involves compulsive behaviors despite treatments. Research suggests it stems from neural process deterioration, particularly in forebrain circuits, impacting mood and cognition.

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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Drug addiction is a persistent compulsive behavioral disorder.
  • Current treatments often fail to eliminate drug-seeking behavior.
  • Addiction is hypothesized to result from the pathological deterioration of neural processes governing affective and cognitive functions.

Purpose of the Study:

  • To review progress in understanding the pathophysiology of drug addiction.
  • To identify key molecular and cellular mechanisms underlying persistent drug use.
  • To explore pharmacologic treatments targeting specific neural circuits.

Main Methods:

  • Review of preclinical and human observations.
  • Analysis of molecular and cellular mechanisms in forebrain circuits.
  • Investigation of dopaminergic system involvement.

Main Results:

  • Enduring changes in ventral striatum and prefrontal cortex circuits are implicated.
  • These circuits receive input from midbrain dopamine neurons.
  • K-opiate receptor targeting shows potential for affective and cognitive benefits.

Conclusions:

  • Understanding the pathophysiology of addiction requires examining neural circuit deterioration.
  • Pharmacologic interventions targeting specific receptors, like K-opiate receptors, may offer novel treatment avenues.
  • Addressing both affective and cognitive deficits is crucial for addiction treatment.