Related Experiment Video
Updated: Jun 28, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
The impact of the IL-11:IL-17 ratio on the chronic periodontitis pathogenesis: a preliminary report
Z Yetkin Ay1, R Sütçü, E Uskun
1Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey. zyetkin@med.sdu.edu.tr
Objective:
An imbalance in the pro- and anti-inflammatory cytokines may be responsible for periodontal breakdown through immune responses. This study aimed to determine the total amount, concentration and ratio of interleukin (IL)-11 and IL-17 in gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients.
Materials And Methods:
Forty CP patients and 20 healthy controls (C) were included. The CP group was divided into two subgroups in line with the probing depth (PD) in GCF-sampling sites (CPa: PD >or= 5 mm, CPb: PD
Results:
The total amount and concentration of IL-11 and IL-17 were significantly lower in the CPa group (P < 0.05). The C group has the highest IL-11:IL-17 ratio, followed by CPb and CPa groups respectively. The ratio was significantly lower in CPa group than the CPb and C groups (P < 0.01).
Conclusion:
Our data confirm that the decreased ratio of IL-11:IL-17 may be a factor, which has shown this imbalance between the cytokines' activities in deeper pockets in our study.
